Russian forces struck Kyiv’s television tower and Moscow warned of impending attacks on other strategic targets as a giant convoy of military vehicles edged closer to the capital.

U.S. President Joe Biden said in his first State of the Union address that Kremlin leader Vladimir Putin had “badly miscalculated” in ordering the invasion of Ukraine would pay a heavy price.

He said the United States would follow other Western states in barring Russian aircraft from its airspace.

Ukrainian President Volodymyr Zelensky said five people had died in the TV tower attack. And he expressed further outrage that one of the missiles struck the adjacent Babiy Yar memorial complex – the site of one of the most notorious mass World War Two murders of Jews.

A powerful missile strike devastated the central square in Kharkiv, Ukraine’s second city, a day after residential areas of the city came under heavy shelling. Ten people died in the latest attack.

Zelensky issued a new, dramatic appeal for Ukraine to be admitted to the European Union, winning the admiration of many in the European Parliament, but his proposed membership bid was unlikely to be taken seriously for some time.

At the TV tower, outside the city centre, Ukrainian media reported several explosions had occurred.

Zelensky expressed outrage at damage to the Babiy Yar complex on the site of a ravine where more than 33,000 Jews were killed over two days in 1941 soon after the Nazis occupied the city.

“To the world: what is the point of saying “never again” for 80 years if the world stays  silent when a bomb drops on the same site of Babiy Yar?” Zelensky, who is Jewish, asked on Twitter.

A spokesman said a Jewish cemetery was damaged and Israel had offered to help repair it.

Zelensky also condemned the bombardment of Freedom Square in Kharkiv as a war crime.

“After such an attack, Russia is a terrorist country,” he said.

Russia denies it is targeting civilians in its campaign ordered after Putin said the West had ignored its calls for “security guarantees”, including an undertaking that Ukraine would never be allowed to join NATO.

Eight years after Russia annexed the  Crimean peninsula and fomented an insurgency in eastern Ukraine, Putin had for weeks denied any intention of invading the country during a mass buildup of troops on its border.

He said the objective of the intervention was the “demilitarisation”’ and “denazification of the country.

The vast convoy of military vehicles making its way towards Kyiv stretched over several km – some quite close together, others spread out, according to satellite photos.

Some analysts said Ukrainian air power was insufficient to inflict much damage on the group as it advanced. Others suggested authorities were waiting for the vehicles to reach Kyiv, where urban war tactics favoured the defender.

But the Russians’ attention was far from being concentrated solely on Ukraine’s two biggest cities.

The southern city of Kherson came under heavy bombardment, though local officials said it remained in Ukrainian hands. Attacks were mounting on the key Sea of Azov port of Mariupol which could serve as a Russian bridge from Eastern Ukraine to Crimea.

More than 70 Ukrainian servicemen were killed in a Russian attack on their military base in Okhtyrka, between Kyiv and Kharkiv.

Death tolls are hard to ascertain or verify.

The U.N. put Ukraine’s civilian death toll as a little over 130, but that figure could be considerably higher.

Ukrainian officials say more than 4,000 Russian servicemen have been Killed as their offensive into the country proceeds more slowly than planned amid stiff Ukrainian.

And U.N officials say more than 600,000 people had left their homes and crossed into neighbouring countries – with Poland and Moldova receiving the biggest share.

In Moscow, where Western unity on sanctions has begun to bite, the stock exchange remained largely closed on Monday and Tuesday. The rouble lost a quarter of its value on Monday and sank to a new low of 117 to the dollar on Tuesday.

Two more U.S.companies – Boeing and Ford – suspended operation in Russia. Oil majors BP and Shell abandoned joint projects with Russian partners.

Two major liberal Russian news outlets were ordered to close operations over their coverage of the war in Ukraine. Ékho Moskvy was told it had been removed from the air because of “calls for extreme activities” its editor in chief, Aleksey Venediktov said he would appeal the ruling. It continued to broadcast on the internet. The second outlet, TV Dozhd (Rain), studied the ruling to determine whether to speak.

A session took place at the U.N. Human Rights Council in Geneva and western representatives walked out as Russian Foreign Minister Sergei Lavrov took the floor.

And the international atomic Energy Agency called a meeting for Wednesday to discuss the effect of war on Ukraine’s 15 working nuclear reactors. Six of the reactors have been disconnected from the grid, an unusually high number.  Nuclear normally covers about 50 percent of Ukraine’s needs.

“We’ve never seen a full-scale war in a country that operates nuclear facilities,” Mycle Schneider, a nuclear consultant, said. “You can’t just decide to shut them down.”